While there is good clinical evidence demonstrating the drug’s efficacy in rheumatoid arthritis and lupus, there are very few studies looking at hydroxychloroquine as a treatment for Sjögren’s. The studies that do exist show mixed results (some show Nonetheless, despite the lack of clinical studies, rheumatologists feel that hydroxychloroquine may have a potential beneficial effect in helping patients with symptoms of fatigue and achiness, which are common complaints in patients with Sjögren’s. Plaquenil and motrin Taking two plaquenil instead of 1.5 Hydroxychloroquine step 1 Chloroquine maculopathy ppt Plaquenil does help with some of the symptoms of Lupus, but it does take a few weeks to start helping. It's most important role is to inhibit progression of the disease -- I'm really surprised you haven't been on it ever since the Lupus was diagnosed. Jun 09, 2012 I have also tried hydroxychloroquine and sulfazalazine both of which caused tinnitus so had to come off them. My consultant has now put my methotrexate up to 25mg to see if my symptoms improve. I'm trying to stay positive but if this doesn't work what other treatment is there. it is so annoying as the combination of methotrexate and. Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. The good news is that hydroxychloroquine targets the immune system without causing an increase in the risk of infection or cancer that can be seen with other immunosuppressant medications. How the drug works is unclear, but recent research has pointed to an inhibitory effect on toll-like receptors that are proteins involved with inflammation. What if plaquenil doesn t work Ask the Expert Plaquenil and Sjögren’s, RA - what else can I try, now on methotrexate, have tried. Plaquenil used for lyme disease Hydroxychloroquine oral tablet doesn’t cause drowsiness, but it can cause other side effects. More common side effects. The more common side effects that can occur with hydroxychloroquine include Hydroxychloroquine Side Effects, Dosage, Uses, and More. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Plaquenil and corona lupus. Does Plaquenil actually work for you? I never actually noticed a difference when I was taking Plaquenil long-term. A few years ago, when I stuck to a super healthy diet, I actually noticed a difference in my symptoms, so I stopped taking Plaquenil. User Reviews for Plaquenil to treat Rheumatoid Arthritis. The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care. Re Plaquenil vs. Methotrexate Hello, I take Plaquenil but I found that I had to take it with Prednisone for the first 2 months until it started to work. I went off of the Predisone after one month but the pain came back so I took it another month and then quit and the Plaquenil worked great and still does.