B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions. Plasmodium falciparum chloroquine resistance Chloroquine resistance mechanism Hydroxychloroquine with tylenol On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. This is a late finding, however, and too late for screening to be useful. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. I don't have a fungus, but I do have peeling nails. Never connected it to my lupus. The reddish puffy rashon your cheeks may be the lupus malar rash. Mine doesn't stay. It isn't every day, and now that I'm on plaquenil, I don't get it at all. Let us know what you learn. B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100). Plaquenil nail changes Pincer nails in a patient with systemic lupus., Plaquenil Oral Uses, Side Effects, Interactions. Plaquenil therapy lupus Answer. Plaquenil or hydroxychloroquine has been known to cause a darkened discoloration of skin and/or mucous membranes. This is considered an adverse reaction and should be discussed with your prescriber. It is important to evaluate this color change to make sure there is nothing else wrong. Skin Discoloration and Plaquenil - Arthritis Information. Lupus and brittle nails, losing eyebrows and rash? - Lupus.. Tips for Dry and Brittle Nails. Some changes in your nails are due to medical conditions that need attention. See your doctor if you have any of these symptoms discoloration dark streaks, white streaks, or changes in nail color Some drugs can induce hair colour changes such as darkening of the original hair colour or repigmentation of grey hair in older people, lightening/bleaching from black or brown to blond hair, greying, reddening or even a complete colour change. These changes can affect scalp, eyelashes, eyebrows, moustaches or all body hair. This means many people taking Plaquenil for RA are taking a dose of 400mg a day or higher. Pigment deposits in the retina can cause vision changes, according to Steven Ofner, M. D. of Eugene Oregon Eye Care. Signs of retinal damage include blurry or distorted vision, flashes of light or floaters, or loss of night vision.