I've stopped Sulfa as I was experiencing a bad taste & smell, which may be caused by sulfa. After a while it wasn't as effective and I too was prescribed methotrexate alongside. I'm about to start MTX & am hoping that I wont have side effects with that! The side effects of the methotrexate for me were horrendous (chronic chest infections) and I'm now asthmatic as a result. Can you bill a plaquenil exam under vision Chloroquine and malaria Chloroquine for treating malaria Taking plaquenil and sulfasalazine Arthritis Information Share I'm new on here but thought it would be a good idea to join a msg board and talk to ppl who are going through the same thing. I have been diagnosed with Limited Scleroderma. My choices are Methotrexate, Plaquenil or Sulfasalzine Azulfidine. I researched them and determined Plaquenil would be my last choice, although it was his first, because I already have lattice degeneration of the retina in both eyes and one of the potential side effects is retinal problems. Sulfasalazine is a type of drug known as a disease-modifying anti-rheumatic drug DMARDmay be used on its own or with other drugs. Sulfasalazine changes the way your condition affects you, and reduces inflammation, pain and swelling in your joints. I had side effects from MTX, which largely wore off, but haven't had any problems with the Hydroxy or Sulpha. I refuse to take it now even if its my passport to biologic treatment. I started with MTX which worked, but not enough so the others were added in which has been better. Sulfasalazine vs plaquenil Plaquenil and sulfasalazine - Autoimmune Disorders - MedHelp, Methotrexate, Plaquenil or Sulfasalazine Azulfidine. Plaquenil used forPlaquenil prevents lupus anticoagulangpt antibodiesAverage weight loss on plaquenilPlaquenil teeth side effectsOct for plaquenil icd10 Sulfasalazine comes as regular and delayed-release enteric-coated tablets. It is usually taken four times a day in evenly spaced doses throughout the day so that no more than 8 hours separates any two doses, if possible. Take sulfasalazine exactly as directed by your doctor. The official site for Sulfasalazine.. Sulfasalazine Side-effects, uses, time to work. Sulfasalazine Azulfidine. Compare Methotrexate vs Sulfasalazine head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Sulfasalazine rated 5.7/10 in overall patient satisfaction. Jan 01, 2006 Combination therapy was associated with significantly fewer withdrawals 8 vs. 29%; P = 0.0008 ; withdrawals as a result of lack of efficacy and adverse events were also lower in the group receiving combination therapy 8 vs. 25% compared with sulfasalazine alone. However, combination therapy was associated with more frequent adverse events, such as infection, gastrointestinal complaints, and cardiovascular disorders. Plaquenil is an arthritis medication and an anti infectious agent. Sulfasalazine is an arthritis medication and an IBD medication. There may be a negative interaction between Plaquenil and alcohol. There may be a negative interaction between Sulfasalazine and alcohol.