Plaquenil retinal screening interval

Discussion in 'Canadian Pharmacy Drugs Online' started by plati1, 13-Mar-2020.

  1. kit1980 Well-Known Member

    Plaquenil retinal screening interval


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    Nov 01, 2015 The incidence of retinal toxicity is associated with the cumulative dose of the drug, increasing significantly beyond 1,000 g of HCQ. This cumulative dose is created when the common dose of 400 mg/day is used for 6.8 years. Hydroxychloroquine is metabolized and secreted by both the liver and the kidneys. Rationale for Screening. Hydroxychloroquine and CQ retinopathy are not reversible, and cellular damage may progress even after the drugs are stopped. When retinopathy is not recognized until a bull’seye appears, the disease can progress for years, often with foveal thinning and an eventual loss of visual acuity. She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to presentation.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Plaquenil retinal screening interval

    Hydroxychloroquine and Chloroquine Retinopathy., Recommendations on Screening for Chloroquine and.

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  6. Refer to the Plaquenil drug label for specific limitations of use for the treatment of malaria. • Plaquenil is also indicated for the treatment of chronic discoid lupus erythematosus and systemic lupus erythematosus in adults, and for the treatment of acute and chronic rheumatoid arthritis in adults.

    • Plaquenil hydroxychloroquine – New Warnings.
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    • Retinal Physician - New Screening Guidelines for..

    Plaquenil prolongs the QT interval. Ventricular arrhythmias and torsades de pointes have been reported in patients taking Plaquenil see OVERDOSAGE. Therefore, Plaquenil should not be administered with other drugs that have the potential to prolong the QT interval see DRUG INTERACTIONS. Discussion. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a patient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth.

     
  7. Zurik XenForo Moderator

    Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Hydroxychloroquine Side-effects, uses, time to work Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses
     
  8. Skakotik Well-Known Member

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Lupus Overlap Diseases What are Common Diseases Associated. An expert on primary Raynaud’s phenomenon describes treatment. Plaquenil and nightmares - Sjogren's World
     
  9. ysafioman Moderator

    WHO Model Prescribing Information Drugs Used Chloroquine should not be taken for prophylaxis by patients with a history of epilepsy. Precautions If the condition of the patient deteriorates after administration of chloroquine, resistance must be suspected and quinine must be administered intravenously as an emergency measure.

    Chloroquine Oral Route Proper Use - Mayo Clinic