Chloroquine and p62

Discussion in 'Chloroquine Phosphate 500 Mg' started by erv, 18-Mar-2020.

  1. AlexNT Well-Known Member

    Chloroquine and p62


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Another widely used autophagy marker, p62, also called sequestosome 1 SQSTM1, binds directly to LC3 and GABARAP Atg8 orthologues family proteins via a short LC3 interaction region LIR. This may serve as a mechanism to deliver selective autophagic cargo for degradation by autophagy. Antimalarial drug chloroquine inhibits autophagy of glioma cells and has been tested as an antineoplastic agent in a small clinical study 25. 10 nM Baf A1 for 2 hours, lysed, and analyzed by immunoblot for p62, an LC3-binding protein and marker of autophagic flux. Degradation of p62 indicates induction of autophagy. b-Tubulin shown as a. Moreover, elevated p62 is significantly correlated with poor survival in patients with breast cancer Supplementary Fig. S1, suggesting a role for autophagy in breast cancer recurrence. CQ is a lysotropic chloroquine derivative that accumulates within lysosomes, resulting in lysosome neutralization and the inhibition of autophagic flux.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine and p62

    FAQs - Autophagy and LC3, Akt and Autophagy Cooperate to Promote Survival of Drug.

  2. What is hydroxy chloroquine
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  4. Moreover, elevated p62 is significantly correlated with poor survival in breast cancer patients Supplementary Figure 1, suggesting a role for autophagy in breast cancer reoccurrence 14-18. HCQ is a lysotropic chloroquine derivative that accumulates within lysosomes, resulting in lysosome neutralization and the inhibition of autophagic flux.

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    Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. Autophagy is a homeostatic cellular recycling system that is responsible for degrading damaged or unnecessary cellular organelles and proteins. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the. In addition to genetic means, autophagy can be disabled by the lysosomal inhibitor chloroquine or by bortezomib, which blocks autophagy via a cathepsin-dependent mechanism resulting in up-regulation of p62. p62 is rich in protein-interacting sequences and contains domains that include a protein-protein interaction module PB1 that facilitates its oligomerization, a ubiquitin-associated UBA 3 domain, and an LC3 interaction region that are essential for p62 function 8, 13, 14.

     
  5. Alisher XenForo Moderator

    Plaquenil (hydroxychloroquine) belongs to a group of medicines called quinolines. Does plaquenil hydroxychloroquine change blood test results. Positive ANA at 80 and now negative. Plaquenil Uses, Dosage & Side Effects -
     
  6. alexzam User

    Chloroquine Drug Interactions - Minor or Nonsignificant - RxList Identify these minor or nonsignificant chloroquine interactions with the RxList drug interaction checker tool.

    Chloroquine Oral Route Proper Use - Mayo Clinic
     
  7. Blein001 XenForo Moderator

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