Side effects of a number of medications also mimic some signs and symptoms of Sjogren's syndrome. Tests can help rule out other conditions and help pinpoint a diagnosis of Sjogren's syndrome. Methotrexate sulfasalazine hydroxychloroquine and leflunomide Natural resources in chloroquine Hydroxychloroquine pustular rash We study how severe was Dry mouth, when it was recovered, drug effectiveness, race, and more among people who take Plaquenil. This study is created by eHealthMe based on reports of 1,993 people who have side effects when taking Plaquenil from sources other than FDA, and is updated regularly. Plaquenil helps most people with rheumatoid arthritis, SLE, DLE, treatment of malaria and the control of malaria symptoms, but it may have unwanted side effects in a few people. All medicines can. The thing is I have not been diagnosed with Sjogren's yet. As I understand taking Plaquenil and seeing if it helps are a part of diagnosis. What makes me unwilling to take the risk, however small it may be, is that I only seem to have two symptoms of Sjogren's dry eyes and Raynaud's phenomenon. I've never noticed any mouth dryness myself. A small piece of filter paper is placed under your lower eyelid to measure your tear production. Your doctor can measure the dryness of your eyes with a test called a Schirmer tear test. Plaquenil dry mouth Sjogren's Syndrome Dry Mouth -, Plaquenil hydroxychloroquine sulfate Drug / Medicine. How does plaquenil work for autoimmune diseasesUfo sign plaquenilPlaquenil and cholesterolHow does plaquenil treat rheumatoid arthritisWhat otc meds can be taken with plaquenil Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. While there is good clinical evidence demonstrating. Ask the Expert Plaquenil and Sjögren’s. Dry eyes, Sjogren’s and Plaquenil.. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. While today it is used to treat autoimmune conditions, such as rheumatoid arthritis and lupus, it was originally used as an anti-malaria drug. Hydroxychloroquine oral tablet is available as a brand-name drug and a generic drug. Brand name Plaquenil. Hydroxychloroquine comes only as a tablet you take by mouth. I also don't find my mouth is as dry. I spoke to my mouth specialist about this and she found this all very interesting. She said that she previously didn't think that Plaquenil helped with dry mouth and eyes, but lately has been hearing the opposite and that I "provided very convincing evidence" that it does help.