DLE is more common and more severe in smokers compared to non-smokers. Smoking also reduces the effectiveness of antimalarials and other therapies. Chloroquine malaria Extraerythrocytic malria and chloroquine Plaquenil is used to keep this autoimmune disease at a less active phase- it is not just for joint pains and discoid It helps to also keep the flares less severe - unsure how it works they just know that it does. Hydroxychloroquine and chloroquine phosphate have shown beneficial effects in treating discoid lupus erythematosus DLE. Additionally, The antimalarial drugs may prevent the development of systemic lupus erythematosus SLE in patients with DLE, and they might decrease the risk of cardiovascular disease. These medications may also prevent lupus from spreading to certain organs, such as the kidney and central nervous system your brain and spinal cord and may help to reduce flares by as much as 50%. Plaquenil and other anti-malarials are the key to controlling lupus long term, and some lupus patients may be on Plaquenil for the rest of their lives. Between 5% and 25% of patients with DLE develop SLE, in which there may be other forms of cutaneous lupus, and other organs may develop the disease. Most patients with DLE just have skin involvement (cutaneous LE). Plaquenil for discoid lupus Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Discoid Lupus Erythematosus Medication Antimalarial agents. Plaquenil and prednisone for lupusHydroxychloroquine tablets ip 200 mgPlaquenil 200 mg ulotkaHydroxychloroquine and sunshineMilk thistle and plaquenil Hydroxychloroquine is a one of a number of drugs which have been used for many years in the treatment of malaria. Fortunately, it was discovered these drugs often are helpful in the treatment of various rheumatic diseases, particularly systemic lupus erythematosus SLE or "Lupus" and rheumatoid arthritis. Plaquenil. A medication for Lupus. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Lupus - Diagnosis and treatment - Mayo Clinic. Plaquenil Hydroxychloroquine may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Lupus Erythematosus. PLAQUENIL is indicated for the treatment of chronic discoid lupus erythematosus and systemic lupus erythematosus in adults. This class of medication can address both mild joint problems as well as the cutaneous findings of lupus. Lupus patients who do not respond to Plaquenil, especially those with discoid lupus, may respond to a combination of quinacrine another antimalarial medication and Plaquenil. Sunscreen for lupus Today, Plaquenil and other antimalarials are also used to treat and help prevent symptoms caused by certain autoimmune diseases such as rheumatoid arthritis RA, systemic lupus erythematosus, and discoid lupus, even though these diseases are not caused by malaria parasites. Plaquenil belongs in a class of medications known as disease-modifying.