Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Hydroxychloroquine flu vaccine Why does hydroxychloroquine cost so much Hydroxychloroquine brand namePlaquenil is a disease-modifying anti-rheumatic drug DMARD approved for adults with RA. It is often given in combination with methotrexate and sulfasalazine a treatment known as triple therapy, to help slow RA disease progression for patients who do not get relief from methotrexate therapy alone. 1,2 May 11, 2017 Other commonly used DMARDs for RA include hydroxychloroquine and sulfasalazine, which can be prescribed alone or with methotrexate. These drugs tend to be a little weaker, but they have fewer side. Second opinion said start on methotrexate, wait on Enbrel. Started 15 mg oral methotrexate in April 2019, with 5 mg daily prednisone. At 3 month appointment in August 2019, doctor wants to slowly taper off prednisone, reducing to 4 mg for a month to prevent a flare, while adding 200 mg hydroxychloroquine twice a day. Recently my eyes have felt sore and, after posting a question on this site, I am seeing my GP on Monday. Thanks Hi Catjones I have been taking this combination, started on both of them in January this year. When to switch from plaquenil to methotrexate Anyone used plaquenil and arava which is better? DailyStrength, Treating Rheumatoid Arthritis DMARDs vs. Biologics. Plaquenil structurePlaquenil side effects gasHydroxychloroquine makes me feel worse GI problems such as nausea and vomiting are the most common side effects associated with methotrexate, affecting between 20and 65 percent of RA patients who take the drug. While hair loss is a relatively uncommon side effect in patients who take methotrexate at such doses, up to one third develop mouth ulcers, or sores. Side effects plaquenil/methotrexate. rheumatoid. Changing from methotrexate and prednisone to methotre. - NRAS. Plaquenil instead of Methotrexate? Polymyalgia Rheumatica and GCA.. Learn when your doctor might switch you to one of these drugs, and how to make the change. like methotrexate, sulfasalazine, hydroxychloroquine, or leflunomide. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. Apr 21, 2017 I had to stop methotrexate about 7 months ago for my RA, due to bad side effects after using it successfully for 10 years. As an alternative, my rheumy put me on HCQS, also known as plaquenil, along with.