In many cases, once the offending drug has been stopped, fading of the lesions occurs. However, the pigmentation may last a long time or become permanent. How does hydroxychloroquine treat lupus Stopping and starting plaquenil Plaquenil fda pregnancy category Mechanism of Toxicity. The mechanism of hydroxychloroquine retinal toxicity has yet to be fully elucidated. Studies have shown that the drug affects the metabolism of retinal cells and also binds to melanin in the RPE, which could explain the persistent toxicity after discontinuation of the medication. The previous ophthalmological examination had been made 3 years before and there was no sign of retinal involvement. A skin biopsy was performed and showed pigment deposition in superficial dermis with haemosiderin characteristics—Perls Prussian staining was positive for iron and Fontana-Masson staining was negative for melanin. Hydroxychloroquine-induced pigmentation lesions usually begin after a few months or years of treatment. When we compared our patients with the controls, we found no significant association with the duration of HCQ treatment or with the cumulative dose of HCQ. Download PDF Many systemic medications may cause retinal toxicity. Because many drugs that induce skin pigmentation also cause photosensitivity reactions, sun protection is usually recommended. Hydroxychloroquine-induced pigmentation Hydroxychloroquine-induced hyperpigmentation in systemic., Woman in grey hydroxychloroquine-induced hyperpigmentation BMJ Case. Hydroxychloroquine sulphate and pregnancySide effects of hydroxychloroquine winDecreased libido plaquenil HCQ is often prescribed for longer durations and may be associated with cutaneous adverse effects such as yellow-brown or slate-grey pigmentation, bleaching of hair, exacerbation of pre-existing psoriasis, cutaneous rashes and pruritus. 1 Cutaneous pigmentation occurs in 10%–30% patients, most commonly over shins. Hydroxychloroquine induced cutaneous pigmentation a.. Hydroxychloroquine-Induced Pigmentation in Patients With.. Skin Pigmentation with Hydroxychloroquine Plaquenil — Donovan Hair Clinic. IMPORTANCE Hydroxychloroquine-induced pigmentation is not a rare adverse effect. Our data support the hypothesis that hydroxychloroquine-induced pigmentation is secondary to ecchymosis or bruising. Skin pigmentation related to use of hydroxychloroquine starts out as a yellow brown to slate gray or black pigmentation on many areas of the body - especially the front of the shins but also the face, forearms, mouth mucosa essentially hard palace and gingivae and nail beds. Hydroxychloroquine pigmentation can occur within 1 year after starting therapy 4, 12, 13, 17. The skin discoloration has no systemic adverse sequelae. The skin discoloration has no systemic.