Non aqueous titration of chloroquine phosphate

Discussion in 'North West Pharmacy Canada' started by Tb.Cyxob, 05-Mar-2020.

  1. BIG XenForo Moderator

    Non aqueous titration of chloroquine phosphate


    All the indicators except the three and four-membered-ring cyclic ethers give sharp end-point inflections in titrations of quinuclidine and 8-hydroxyquinoline, but for caffeine only the acetal indicators are satisfactory. Relative standard deviations obtained in replicate determinations of 0.1-mequiv.

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    Combine the chloroform extracts and evaporate to a volume of about 10 ml. Add 40 ml of anhydrous acetic acid and carry out non aqueous titration, determining the end point potetiometrically. Each ml of 0.1M perchloric acid VS is equivalent to 25.79 mg of Chloroquine Phosphate. Calculation Employ the developed method for analysis of chloroquine phosphate in pharmaceutical dosage forms, and to compare between the developed method and the official methods for analysis of chloroquine phosphate formulations. The zero order absorption and first derivative spectra were measured for chloroquine phosphate Dimethoxymethane, 1,3,5-trioxane, 1,3-dioxolane and alicyclic ethers with three-to seven-membered rings were evaluated as thermometric end-point indicators in the non-aqueous titration of weak organic bases including some basic drugs, in the free form and as hydrochlorides, phosphate and tartrate, with perchloric acid in acetic acid.

    In the drug titrations, the acetal indicators give the sharpest end-point inflections for chloroquine phosphate. Amounts range from 0.10 to 0.66%, with sample and titrant delivery errors making a significant contribution.

    Non aqueous titration of chloroquine phosphate

    Ionic polymerisation as a means of end-point indication in., Application of Derivative Spectrophotometer for Analysis of Chloroquine.

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  7. Methods The complex formation between chloroquine phosphate and chloranilc acid as evidenced by the instantaneous change in colour of a solution of chloranilic acid in dioxan from yellow to purple upon addition of a solution of chloroquine phosphate in chloroform was monitored spectrophotometrically to determine the wavelength of maximum.

    • Spectroscopic Studies of the Electron Donor-Acceptor..
    • Ionic polymerisation as a means of end-point indication in non-aqueous..
    • Uncertainty evaluation in the chloroquine phosphate potentiometric..

    A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Pharmacopeia USP 3. BP describes non-aqueous titration with perchloric acid as titrant where the end point is located potentiometrically. USP describes a UV-spectrophotometric method, where the absorbance of CQP in HCl medium is measured at 343 nm. The result of the non-aqueous titration of the pure quinine sulphate powder and the three tablet brands is presented in Table 1. The pure quinine sulphate powder and brands B and C had values within the range specified in the B. P. of 99 – 101%w/ v for pure compound and 95 – 105%w/v for the tablet dosage form Table 1.

     
  8. Standby Guest

    It got so I couldn't walk up a curb without help before I switched to oral Methotrexate. Here are the side effects: be sure your doctor looks at this. Will you have Chest pain with Plaquenil - eHealthMe Hydroxychloroquine - thigh muscle weakness? Plaquenil Side Effects Go Away? DailyStrength
     
  9. Tayson Guest

    Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. Healthboards - Immune & Autoimmune - Lupus Plaquenil and hairloss Plaquenil Use in Autoimmune Diseases Hydroxychloroquine plaquenil withdrawl? - LUPUS UK
     
  10. unnamed777 XenForo Moderator

    Plaquenil Side Effects on Your Eyes and Vision If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage.

    Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.