Part of that is due to less exercise, part due to having no appetite thus feeling like anything I can get down is ok. Well, now I've been exercising at almost my pre-Lupus rate (ran a marathon a year before), eating a more moderate diet (clean protein, vegs & fruits), and am no longer taking that weight & bloat causing Prednisone (off Pred almost 2 yrs now). My question: Do you feel like you've gained weight on Plaquenil (ie without Prednisone)? Can you stop plaquenil right away Plaquenil malaria prevention Hence, if the loss of appetite and weight loss started after you started on this drug, then yes, it could be due to Plaquenil. However, if you had loss of appetite and weight loss before your started this drug, then the drug can aggravate the process. In this case, the cause of loss f appetite and weight loss has to be found. Doctors give unbiased, trusted information on whether Plaquenil can cause or treat Weight Gain Dr. Valdez on hydroxychloroquine and weight gain Depression can cause weight gain and loss, but alopecia not a common sign of depression. Hydroxychloroquine received an overall rating of 7 out of 10 stars from 368 reviews. See what others have said about Hydroxychloroquine, including the effectiveness, ease of use and side effects. My Lupus has been really quiet for about 2 yrs, and I'm afraid to change anything. The Plaquenil drug side effects list weight loss, but some people have reported weight gain instead. My rheumy wants me to come down and then off my Plaquenil, but I've been resisting simply because I'm afraid to. Can hydroxychloroquine cause weight loss Plaquenil Side Effects Common, Severe, Long Term -, Hydroxychloroquine and weight gain - Answers on HealthTap Hydroxychloroquine retinopathy screening Hydroxychloroquine oral tablet doesn’t cause drowsiness, but it can cause other side effects. More common side effects. The more common side effects that can occur with hydroxychloroquine include Hydroxychloroquine Side Effects, Dosage, Uses, and More. Hydroxychloroquine Reviews Everyday Health. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Aug 01, 2009 If you're on steroids that can be whats causing you to gain weight. I can't offer any advice on losing the weight if you come off the Plaquenil. Like Joy said, Plaquenil is the first medication they use in treating lupus. It has the least amount of side effects and seems to work well for most patients. Some patients can not take the generic. Find reviews for Hydroxychloroquine from other patients. Learn from their experiences about effectiveness, side effects and cost. Dismiss this notification PatientsLikeMe would like to remind you that your browser is out of date and many features of the website may not function as expected. Summary Weight loss is found among people who take Hydroxychloroquine sulfate, especially for people who are female, 2-9 old, have been taking the drug for 1 - 2 years, also take medication Enbrel, and have Juvenile rheumatoid arthritis.