Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Hydroxychloroquine dosage calculator Drug information about chloroquine Talk to your doctor about this, but my guess is that the Plaquenil is not doing anything to cause the pain, but rather that it is not doing enough to prevent it. It sounds like your RA has probably gotten a bit out of control, relative, to your current treatment, and Plaquenil is not a particularly potent drug when it comes to managing joint pain. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Apr 28, 2009 And, as far as Plaquenil and eye problems, the Ophthamologists I've talked to including a Neuro Ophthalmologist say that while Plaquenil can cause serious damage to the optic nerve, it's very rare. Annual appointments with an ophthalmologist are important in order to catch any problems early. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Can plaquenil cause extreme fatigue Stomach problems with Plaquenil • Johns Hopkins Arthritis Center, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Where can i buy chloroquineHydro hydroxychloroquineWhen taking aralen should i be using an antiacidPlaquenil for itp Hydroxychloroquine Plaquenil and generics can itself cause fatigue in some users, it can interrupt sleep patterns especially by causing more vivid dreams which in turn makes one more tired. The drug can also lower blood counts red cell, white cells and others too which in turn can cause fatigue. Is lethargy and tiredness a side effect of hydroxychloroquine?. Plaquenil and muscle aches and pains?. Extreme fatigue on Plaquenil? lupus. Walking up stairs, fetching groceries, or doing household chores can all make you feel like you’ve tried to climb Everest or run a marathon. You’re dizzy and lack balance. Extreme fatigue may affect a person’s sense of balance, particularly when they stand up from sitting or lying down. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Jul 16, 2018 I have had this happen with other meds in the past and so eventually I realized it might be a reaction to the plaquenil. So I went off of it. Everything cleared up and I went back to normal. However, then my fatigue returned. After several months off of plaquenil, I went back on it, deciding to stick with the 100 mg per day.