Synthesis of chloroquine from m-chloroaniline

Discussion in 'Northwest Pharmacy' started by topolib, 18-Mar-2020.

  1. Gatter Well-Known Member

    Synthesis of chloroquine from m-chloroaniline


    Chloroquine phosphate is a white, odorless, crystalline powder having a bitter taste: it discolors gradually on exposure to light. The fluorescence spectrum of chloroquine phosphate obtained on a solution of 0.2 mg/ml p H 7.9 phosphate buffers using an Aminco–Bowman spectrophotofluorometer.

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    Synthesis of New 4-Aminoquinolines and Evaluation of Their In Vitro Activity against Chloroquine-Sensitive and Chloroquine-Resistant Plasmodium falciparum Chandima S. K. Rajapakse, 1, ¤ Maryna Lisai, 1 Christiane Deregnaucourt, 2 Véronique Sinou, 3 Christine Latour, 3 Dipankar Roy, 1 Joseph Schrével, 2 and Roberto A. Sánchez-Delgado 1, * Sep 15, 2009 Synthesis and antimalarial activity of new chloroquine analogues carrying a multifunctional linear side chain Daniel P. Iwaniuk, 1 Eric D. Whetmore, 1 Nicholas Rosa, 1 Kekeli Ekoue-Kovi, 1 John Alumasa, 1 Angel C. de Dios, 1, 3 Paul D. Roepe, 1, 2, 3 and Christian Wolf 1, 3 One of the earliest and most effective antimalarials is chloroquine, in whose synthesis 4, 7-dichloroquinoline prepared from 7-chloro-4-quinolone is the key intermediate. Chloroquine is readily absorbed from the gastrointestinal tract and about 50% in the circulation is bound to plasma protein.

    Chloroquine phosphate exists in two polymorphic forms giving rise to two melting ranges. Chloroquine phosphate exhibits essentially no optical activity, existing as a racemic mixture.

    Synthesis of chloroquine from m-chloroaniline

    Synthesis of chiral chloroquine and its analogues as., Synthesis and antimalarial activity of new chloroquine.

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  4. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication.

    • Chloroquine - Wikipedia.
    • Chloroquine - ScienceDirect.
    • Synthesis and Evaluation of Chloroquine-Containing DMAEMA..

    The synthesis of deuterated chlorhexidine hydrochloride is reported. The specific labelling of the saturated chain is achieved through the combination of the previously reported synthesis of 2,2,3,3,4,4,5,5‐ 2 H 8 ‐hexane‐1,6‐diol and a synthesis of carbon‐14 labelled chlorhexidine. Before the administration of chloroquine, the patient had only a mild skin erythema in the irradiated area, which was consistent with the radiotherapy dose she had received. On day 3 of chloroquine therapy, she developed localized brisk bullous eruptions in the irradiated area, which developed into a patch of fulminant moist desquamation. A New Synthesis of Chloroquine

     
  5. eXtrim Well-Known Member

    However, there seems to be a breakthrough as it has been announced recently that Chloroquine Phosphate is the new discovery that will help battle this life-threatening virus. Chloroquine - FDA prescribing information, side effects and uses Chloroquine Does NOT Cure Coronavirus! Dubawa Breakthrough Chloroquine phosphate shows efficacy in.
     
  6. -BRAIN- Moderator

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Hydroxychloroquine Plaquenil Mefloquine - Wikipedia CDC - Malaria - Malaria Worldwide - How Can Malaria Cases and.
     
  7. stopinator Guest

    The Efficacy of Artesunate, Chloroquine, Doxycycline. In the present study, artesunate, chloroquine, doxycycline, primaquine and artesunate+primaquine have been shown to display therapeutic activity against P. gallinaceum compared to the IUC group. However, chloroquine and doxycycline revealed better efficacy in treating infected chickens at the gametocyte stage than artesunate and artesunate.

    Primaquine – Malaria Site