Chloroquine and hydroxychloroquine for cancer therapy

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  1. marmalade New Member

    Chloroquine and hydroxychloroquine for cancer therapy


    Based on their findings, first study author Ciska Verbaanderd, from the University of Leuven in Belgium, and her colleagues say that the drugs “deserve further clinical investigations in several cancer types.”The review was recently published in the journal . While the United States has seen a fall in cancer death rates in recent years, the disease remains a significant burden on public health. Given that cancer is increasingly becoming resistant to existing therapies, there is a desperate need to uncover new ways to fight the disease.

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    Advancements in treatment have also been made by combining new drugs with repurposed old drugs that can enhance therapeutic effects or specificity. Chloroquine, a drug that has historically been used to treat malaria, has recently been combined with a new drug, Tarceva, which kills lung cancer cells. Tarceva only works for some patients, and the cancer almost always becomes resistant after Along the lines of the Trial Watch series published on a monthly basis in OncoImmunology,35-38 here we summarize the dual role of autophagy in oncogenesis and tumor progression and discuss recent clinical trials investigating the use of chloroquine CQ, hydroxychloroquine HCQ in cancer patients. Two inhibitors chloroquine or hydroxychloroquine were evaluated in all cancer types. It may be different in different cancer types. In addition, some studies have reported only short-term follow-up and lack of long-term outcomes. Because of the data limitation, we did not evaluate the safety of autophagy inhibition used in the cancer treatment.

    CQ and HCQ are medications used to prevent and treat malaria. Last year, there were more than 1.6 million new cancer cases diagnosed in the U. Verbaanderd and colleagues believe that the drugs CQ and HCQ could help in this fight.

    Chloroquine and hydroxychloroquine for cancer therapy

    Repurposing Drugs in Oncology ReDO—chloroquine and., Chloroquine and hydroxychloroquine for cancer therapy

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  4. Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria.

    • Hydroxychloroquine Uses, Dosage & Side Effects -.
    • The clinical value of using chloroquine or hydroxychloroquin..
    • Antimalarial drugs could support existing cancer treatments..

    Chloroquine and hydroxychloroquine are both well-known antimalarial agents. Preclinical studies have supported the use of these drugs for anti-cancer therapy, particularly when used together with conventional anti-cancer treatments because they can sensitize tumor cells to many drugs. This results in potentiation of the therapeutic activity. Hydroxychloroquine is a substance that decreases immune responses in the body. Palbociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Estrogen can cause the growth of breast cancer cells. Drugs, such as letrozole, may lessen the amount of estrogen made by the body. Indeed, current clinical trials are trying to use chloroquine or hydroxychloroquine, alone or in combination with other drugs to inhibit autophagy during breast cancer therapy since chemotherapy and radiation, regimens that are used to treat breast cancer, are known to induce autophagy in cancer cells.

     
  5. DrTimHideR Moderator

    Chloroquine is an anti-malaria medicine that works by interfering with the growth of parasites in the red blood cells of the human body. CHLOROQUINE PHOSPHATE, USP Chemical Database Chloroquine Chloroquine Side Effects Common, Severe, Long Term -
     
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  7. moscowdip Moderator

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    Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria